Santa Clara's Abel Santamaría Airport receives several weekly flights from Montreal, Toronto and Calgary, plus a Copa Airlines flight to Panama City on Tuesday/Sunday, and is now the country's third-most-important airport. There are no flights to Havana.
The Terminal de Ómnibus Nacionales, which is also the Víazul bus station, is 2.5km west of the center, out on the Carretera Central toward Matanzas, or 500m north of the Che monument. Tickets for air-conditioned Víazul buses are sold at a special 'foreigners' ticket window at the station entrance.
Cayo Santa María
3:35am, 8:40am, 4:50pm
Santiago de Cuba
12:10am, 1:45am, 9:50am, 7pm
The Santiago de Cuba bus travels via Sancti Spíritus (CUC$6, 1¼ hours), Ciego de Ávila (CUC$9, 2½ hours), Camagüey (CUC$15, 4½ hours), Holguín (CUC$26, 7¾ hours) and Bayamo (CUC$26, 9¼ hours).
The Cayo Santa María bus also stops in Remedios (CUC$7, one hour) and Caibarién (CUC$7, 1¼ hours)
The intermunicipal bus station, west of the center via Calle Marta Abreu, has cheap local buses to Remedios, Caibarién and Manicaragua (for Embalse Hanabanilla). Transport could be by bus or truck, gets overcrowded and isn't 100% reliable.
Casa owners usually know schedules, or will find them out on your behalf.
Colectivo (shared) taxis hang around the Terminal de Ómnibus Nacionales to drum up custom for the journey to Havana. The best time to catch them is just before the scheduled Víazul departures. They'll whisk you to addresses in Central Havana in three hours for CUC$35 (less if you bargain hard), but they only leave when full (four people).
Notoriously erratic trains pass by en route to Santiago de Cuba via Camagüey. In the other direction, they run to Havana, usually via Matanzas. Due to their fickle nature and depressingly bad facilities, few foreigners use them.