The bus station is northeast of the city center. There are no Víazul services to or from Manzanillo. This narrows your options down to local Cuban guaguas (buses) or trucks (no reliable schedules and long queues).
Sunwing flies directly from Toronto and Montreal into Sierra Maestra Airport in winter and transfers people directly to the Marea del Portillo hotels.
Cuba's slow national train service with trains to Havana every fourth day.
Flights from Ft. Lauderdale, Florida three times per week.
Rents cars and mopeds.