Aeropuerto Guillermo León Valencia is right behind the bus terminal, 1km north of the city center. Avianca (www.avianca.com) and EasyFly (www.easyfly.com.co) fly direct to Bogotá.
The bus terminal is 1km north of the city center. There are frequent services to Cali (COP$17,000, three hours). Direct buses to Bogotá (COP$100,000, 12 hours) and Medellín (COP$91,000, 11 hours) depart in the evenings.
There are regular minibuses to San Agustín (COP$35,000, five hours); most companies require a change of vehicle but Sotracauca offers a direct service.
Buses to Tierradentro (COP$25,000, five hours) leave at 5am, 8am, 10:30am, 1pm and 3pm. The 10:30am service takes you all the way to the Museo Arqueológico entrance.
Hourly buses connect to Pasto (COP$35,000, six hours) and Ipiales (COP$40,000, eight hours). Security on the road from Popayán to the Ecuadorean border has improved and robberies are no longer common, but it's best to travel during the day if possible when you'll also be able to admire the amazing views.