Aeropuerto Guillermo León Valencia is 1km north of the city center. There are up to four flights daily to Bogotá with Avianca (www.avianca.com) and EasyFly (www.easyfly.com.co).
The Terminal de Transporte Popayán is 1km north of the city center. There are frequent services to Cali (COP$23,000, three to four hours). Direct buses to Bogotá (COP$110,000, 12 to 14 hours) and Medellín (COP$98,000, 11 hours) depart in the evenings.
There are regular minibuses to San Agustín (COP$37,000, five hours); most companies require a change of vehicle but Sotracauca offers a direct service four times daily.
Buses to Tierradentro (COP$26,000, five hours) leave at 5:30am, 8:30am, 10:30am, 1pm and 3pm. The 10:30am service takes you all the way to the Museo Arqueológico entrance.
Hourly buses connect to Pasto (COP$37,000, six hours) and Ipiales (COP$42,000, eight hours). It's best to travel during the day if possible, when you'll also be able to admire the amazing views.