The city's zona rosa (nightlife zone) is around Parque Lleras in El Poblado, a dense tangle of upscale restaurants, bars and clubs. Some of Medellín's most exclusive bars are located along Av El Poblado. Less showy are the bars around the Laureles neighborhood. For a more bohemian experience, check the options around Parque del Periodista in the center.
There is a group of large clubs in the former industrial neighborhood of Barrio Colombia. Many late-night options are clustered on the Autopista Sur – the southern highway out of town near the Palmahia disco. Bars in that area don't get busy until around 3am and keep going until first light.
Second only to Bogotá when it comes to the craft-beer scene, Medellín boasts around three dozen microbreweries and nano-breweries. A number are one-person operations, with the self-taught brewers experimenting in their kitchens and serving their beers in their front rooms, while others have proper steel vats and formal brew-master skills. Brews to look out for include TorreAlta, Metamorphosis, Belgian-style ÖlBröder, Alburrá Valley and Sierra Blanca – none have brewpubs of their own but are available in bars and restaurants around Medellín.