The city's zona rosa is around Parque Lleras in El Poblado, a dense tangle of upscale restaurants, bars and clubs. Some of Medellín's most exclusive bars are located along Av El Poblado. Less showy are the bars around the Laureles neighborhood. For a more bohemian experience, check the options around Parque del Periodista in the center.
There is a group of large clubs in the former industrial neighborhood of Barrio Colombia. Many late-night options are clustered on the Autopista Sur – the southern highway out of town near the Palmahia disco. Bars in that area don't get busy until around 3am and keep going until first light.