Travel in the Caribbean is not particularly easy for those with physical disabilities. Overall there is little or no awareness of the need for easier access onto planes, buses or rental vehicles. One exception is Puerto Rico, where good compliance with the Americans Disabilities Act (ADA) means many sights and hotels have wheelchair accessibility.
Visitors with special needs should inquire directly with prospective hotels for information on their facilities. The larger, more modern resorts are most likely to have the greatest accessibility, with elevators, wider doorways and wheelchair-accessible bathrooms.
While land travel may present some obstacles, cruises are often a good option for travelers with disabilities in the Caribbean. Many cruise lines can coordinate shore-based excursions in tour buses equipped for special needs.
The Society for Accessible Travel & Hospitality has useful information.
Download Lonely Planet's free Accessible Travel guide from http://lptravel.to/AccessibleTravel.