This agency's owner, Chris Clark, a no-nonsense Scotsman, has spent decades helping to protect – and establish responsible ecotourism in – the gorgeous animal-rich Reserva Extrativista Baixo Rio Branco-Jauaperi, also known as Xixuaú-Xipariná. He still specializes in highly recommended trips there but also runs tours from Novo Airão to the Anavilhanas Archipelago and elsewhere.

Plan on at least a week if going to the Xixuaú, two weeks for the Xipariná.