Potosí boasts one of the world’s highest airports, Aeropuerto Capitán Rojas. However, unless you're the president, you won't be flying here. There are no operating commercial flights. Sucre's Alcantarí International Airport is 121km away.
Bus & Shared Taxi
All road routes into Potosí are quite scenic and arriving by day will always provide a dramatic introduction to the city. The new bus terminal is about 2km north of the center on Av Las Banderas and nearly all flotas (long-distance buses; except for Uyuni) depart from here. Micros I or A run between the bus terminal and the cathedral.
There are direct flotas to La Paz, but in many cases it can be quicker to look for a connection in Oruro. Similarly for Sucre shared taxis (B$50, 2¼ hours) are pricier than the flotas, but are faster and more comfortable and can pick you up at your hotel. Try Cielito Express or Correcaminos; if solo, it's quicker to go to their offices behind the old bus terminal as they won't depart without a full car.
For Uyuni (B$40, five hours) buses depart from the old terminal 15 minutes downhill on foot from the center on Av Universitaria roughly every half hour from 7am to noon and then several more in the early evening. The rugged 210km route is quite breathtaking. Micros to Tarija also depart from this location.
Autobuses Quirquincho (www.autobusesquirquincho.com) and two other companies service Buenos Aires, Argentina.