From Santa Cruz, trufis leave for Yapacaní (B$23, two hours) from Izozog (Isoso). Make it clear that you want to get off at Buena Vista. Returning trufis cruise around the plaza with horns blaring in search of passengers. Most go only as far as Montero (B$10, one hour), but you can catch a quick and easy onward connection to Santa Cruz there.
Moto-taxis loiter at the southwestern corner of the plaza and are a convenient way to get out into the countryside.