About 20km north of Buenos Aires is peaceful and residential San Isidro, a salubrious suburb of leafy cobblestone streets lined with some luxurious mansions, as well as more modest houses. The historic center is at Plaza Mitre with its beautiful neo-Gothic cathedral; on weekends the area buzzes with a crafts fair. There are a number of worthwhile museums with sweeping river views that make for a pleasant day trip from the city. The suburb is easily reached by train from Buenos Aires; it's also possible to stop here on the way to or from Tigre.

San Isidro is steeped in history dating back to the first settlement of Buenos Aires in 1580, when Juan de Garay divided a 20km stretch of coastline into narrow strips of land that were divvied up among the group of 40 who had made the journey from Spain.