Hikers can access a beautiful day-long hike to the Cueva de las Manos via Cañon de las Pinturas, with gorges and excellent scenery. There's access from the north (via Hostería Cueva de las Manos) and from the west (via Estancia Casa de Piedra; nonguests pay AR$60 for access). Get an early start and bring your own food.
Guides can be contracted, but the trail is clear enough to go without one.
From Estancia Casa de Piedra, it’s 12km to the canyon, then another 6km to the cave – it's about 10 hours for the roundtrip.