Leiden's Centraal Station is bright and modern and there are lockers near platform No 5. Trains to and from Amsterdam take around half an hour and a trip to Schiphol Airport about 20min. Regional and local buses leave from the bus station directly in front of Centraal Station.
Leiden is compact and you'll have a hard time walking for more than 20min in any one direction. The bicycle shop in Centraal Station is around the back.
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