The best price found from United States to Uzbekistan is on October 10th, 2016, travelling with Aeroflot. See more options, compare prices and book: search flights.
If arriving by air, your grand entrance into Uzbekistan will most likely occur at Tashkent International Airport. A few flights from Russia arrive in regional hubs such as Samarkand, Bukhara and Urgench.
The numerous aviakassa (private ticket kiosks) scattered around major cities can help book international tickets on national carrier Uzbekistan Airways and other airlines.
Uzbekistan Airways has convenient booking offices in Tashkent, but frustratingly in most cities you'll need to buy domestic flights in the airports themselves, as they were not available online or through aviakassa at the time of writing. Pay for airline tickets in US dollars only.