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I am not exactly sure which company serves the Pereira-Honda route, but I am willing to bet Rapido Tolima does. You might be able to access the Pereira website and find out for yourself. However, I do know for a fact that Rapido Tolima rolls through both Honda and Rio Claro on both the Ibague-Medellin route and the Bogota-Medellin route. I traveled from Medellin to Ibague on Rapido Tolima during the holidays and the bus stopped in both towns. The Honda-Rio Claro route is relatively flat and shouldn't take more than a few hours. The leg from Pereira to Honda will probably take a significantly longer amount of time; due to the fact that you have to cross some pretty big mountains. If you leave early, I do think the trip can easily be done in a day (depending on road conditions in the mountains). Good luck and enjoy Colombia!