Anti-malarials and pregnancy
Replies: 3 - Last Post: Oct 11, 2012 9:36 PM Last Post By: nutraxfornerves
Oct 10, 2012 7:02 AM
Anti-malarials and pregnancyI'm pulling this post out of another thread
There does not seem to be evidence that antimalarials might interfere with conception, but there are issues with taking antimalarials while pregnant. It's suggested that a woman not try to conceive until the antimalarial is completely gone from her system. I'm going to copy from a previous post of mine; it's a response to someone who was going to honeymoon in Kenya. Because the post is old, I looked at the original sources to be sure the info is still good.
You may be interested in this from the UK Health Protection Agency. It is based on how long it takes various antimalarials to be completely gone from your system. Do note that if you will not be using contraception during your trip, because you are hoping to become pregnant, you should NOT take doxycycline as it can interfere with development of bones & teeth of the fetus. It can also interfere with certain oral contraceptives. Also note that the UK HPA says risk from other antimalarials is more theoretical than real. There is too little experience with Malarone to be sure it is safe during pregnancy, but it looks like it might be OK. For mefloquine (LAriam) they say "Women who have taken mefloquine inadvertently just prior to or during the first trimester should be advised that this does not constitute an indication to terminate the pregnancy."
If a female traveller is planning to conceive during a visit to a destination with a high risk of contracting chloroquine-resistant falciparum malaria, expert advice should be sought.
• Mefloquine (Lariam, Mefliam, Tropicur, Mephaquin & others): 3 months.
• Doxycycline (Vibramycin and many others): 1 week.
• Atovaquone/proguanil (Malarone, Malanil): 2 weeks.
The US CDC says "Because there is no evidence that chloroquine and mefloquine are associated with congenital defects when used for prophylaxis, CDC does not recommend that women planning pregnancy wait a specific period of time after their use before becoming pregnant. "
After your return, be sure to check with your doctor any time you think you have come down with "Flu-like illness" (chills, fever, headache, fatigue, etc). The species of malaria that can show up a few months after your return is still susceptible to chloroquine. So that is what you would be treated with. Chloroquine is considered safe in all trimesters. You need a second drug to be sure all the parasites are gone from your liver, but that drug is not safe during pregnancy, so you would take it after delivery.
Oct 10, 2012 3:32 PM
Oct 11, 2012 8:54 PM
Oct 11, 2012 9:36 PM
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