Mexico City to Panama City

Mexico City to Panama City information and booking

  • Duration
  • Physical rating
  • Culture Shock
Check prices & availability

Schedule Details

Departs from
Mexico City
Cabin, Camping (with basic facilities), Camping (with facilities), Guesthouse, Hotel
Group Size
Maximum of 22 travellers per group
Honduras airport tax
Boat, Overland vehicle, Plane
Important Notes
1. This trip is run by our experienced overland partner Dragoman. 2. Please note that this trip requires minimum numbers to depart, and may be cancelled up until 56 days prior to departure. The places showing on the dates and availability page are an indication only so please contact Intrepid to check if your preferred date will depart before making any final arrangements, such as booking non-changeable flights.


View ancient Mayan ruins in Mexico , Enjoy three nights in the colonial town of San Cristobal de Las Casas, Be left awestruck by the ruined city of Palenque, Learn the history of the clifftop Maya-Toltec ruins at Tulum, Discover the stunning Belizean island of Caye Caulker, Get adventurous in San Ignacio, Belize’s adventure capital, Stay with a Guatemalan family in Totonicapan, Go on a spending spree at Chichicastenango’s markets, Explore the charming colonial city of Antigua

Tour description provided by Intrepid

As far as ultimate Central American adventures go, this trip from Mexico to Panama ticks all the boxes. Starting in Mexico City, the tour ventures down through Mexico, Guatemala, Honduras, Nicaragua, Costa Rica, and finally to Panama. Loaded with culture, history, architecture and bountiful nature, this incredible Central American adventure will leave you breathless. This exciting itinerary may be full of trekking up volcanoes, exploring vibrant cities, kayaking down emerald rivers, snorkelling over reefs and taking part in all manor of outdoor and cultural activities, but there is also a great balance of down time too, with beaches, forests and unspoilt nature to be enjoyed and relaxed in. So if you’re after a life-affirming, awe-inspiring and never-to-be-forgotten adventure, then this epic trip is it.


Day 1 Mexico
Spend time exploring the sights and sounds of intriguing Mexico City. Perhaps check out the pyramids of Teotihuacan or get out among the city’s vibrant nightlife.
Days 2-3 Oaxaca
Enjoy staying at a traditional posada. Take a look around the resplendent colonial city of Oaxaca before taking a guided tour around the Zapotec Ruins.
Days 4-6 San Cristobal De Las Casas
Stay in a family run hotel and enjoy a boat trip down the Sumidero Canyon during a stay in the lovely San Cristobel de las Casas.
Day 7 Frontera Corozal
An early start and full day's drive take us to Frontera Corozal.
Days 8-9 Palenque
Encounter the ancient Mayan city of Yaxchilan en route to Palenque, where the sight of this incredible, ruined city rising from the jungle is truly something to behold.
Day 10 Merida
As the state capital of Yucatan, Merida boasts thriving markets and a bustling nightlife.
Days 11-12 Tulum
Reach the Caribbean Coast for some blissful camping on a remote beach near Xpu Ha. Then, venture to the alluring clifftop ruins of Maya-Toltec.
Days 13-15 Caye Caulker
Wave goodbye to Mexico as a boat trip moves on to Caye Caulker in Belize. Relaxing to the max is compulsory on this idyllic Caribbean island.
Days 16-18 San Ignacio
Head to the Belize mainland, where there’s time to have a nosey around Belize City before moving on to San Ignacio – a beautiful town with lots of outdoor activities to enjoy or a place to simply relax.
Day 19 Tikal
Drive across to Guatemala and be dumbstruck by the Mayan ruins of Tikal, with its temples hiding among the tropical jungle.
Days 20-21 Poptun
Get to know what local life is like in Guatemala while spending time on a working farm in Poptun.
Day 22 Rio Dulce
Soak up the unique Caribbean feel of the town and enjoy a splash in the local hot pools.
Days 23-26 Panajachel/Lake Atitlan/Chichicastenango
Soak up the atmosphere of Panajachel, which is situated on the shores of the beautiful Lake Atitlan. Perhaps embark on an optional boat trip around the lake that takes in the surrounding villages. The following day, visit Chichicastenango and its fantastic, multi-coloured market.
Day 24 San Andres Itzapa
Jump aboard another boat and travel along the Rio Dulce to arrive in San Andres Itzapa where we spend the night at a community project assisting victims of domestic violence.
Days 27-28 Antigua
Appreciate the last couple of days in Guatemala by delving into the charms and wonder of Antigua.
Days 29-30 Los Cobanos
Ease into El Salvadorian life with a stay in the fishing village of Los Cobanos.
Day 31 Cerro Verde National Park
Experience amazing views of surrounding volcanoes and countryside in Cerro Verde National Park.
Day 32 Suchitoto
Wander the colourful streets of Suchitoto, which are lined cobblestone roads that lead to beautiful whitewashed houses.
Days 33-34 Copan
Get up close to the ancient ruins of Copan, one of Honduras’s most striking Mayan sites.
Days 35-37 Roatan Island
Relax in the blissful, crystal-clear waters of Roatan Island, home to gorgeous beaches, intriguing mangroves and the Mesoamerican Barrier Reef, second in size only to Australia’s Great Barrier Reef.
Day 38 Lake Yojoa
Visit Lake Yojoa, where an overnight lakeside camp is the ideal opportunity to take in the surroundings.
Days 39-40 Leon
Enter Nicaragua and head to the university town of Leon, peppered with derelict buildings and walls adorned with political murals and graffiti.
Days 41-42 Granada/Masaya National Park
Experience the wondrous crater and lava flows belonging to the active volcano in the heart of the Masaya National Park.
Days 43-44 Ometepe Island
Cross Lake Nicaragua, Central America’s largest lake, to Isla Ometepe, where two volcanoes, lush vegetation and a wide range of wildlife await.
Days 45-46 La Fortuna/Arenal Volcano National Park
See Arenal Volcano and marvel at this beautiful area's majesty.
Days 47-48 Monteverde
Stay within the rainforest at Costa Rica’s Monteverde, and perhaps witness some of the diverse local flora and fauna during a visit to the Cloud Forest Reserve.
Days 49-50 Manuel Antonio National Park
Sleep in cabins set within the jungle in Manuel Antonio National Park, embarking on jungle walks, relaxing on palm-lined beaches or swimming in cerulean waters.
Days 51-52 Boquete
Panama’s ‘wonderland’, Boquete, offers activities like rafting, hiking and volcano walks, as well as lush tropical forests.
Day 53 Santa Clara
An ideal opportunity to relax, swim in the lovely Pacific Ocean and camp by the beach before heading to Panama City.
Days 54-55 Panama City
Visit the Panama Canal with enough time left to explore the city’s colourful neighbourhoods and soak up the last of the Central American atmosphere.