Reason enough to come to Florence, this fabled museum contains quite simply the world’s finest collection of Renaissance art, including both 12th- to 14th-century forebears and 16th- and 17th-century inheritors. Its 50-plus rooms are crammed with more than 1500 works, nearly all of them masterpieces. Part of the museum’s mystique is the difficulties it presents: long lines, crowded galleries, a daunting combination of quantity and quality. There are two tricks to enjoying your experience: pre-book tickets and concentrate on select artists or periods. While signage is less than satisfying, the museum is laid out chronologically, and largely over a single floor. For a mental-health break, head to the roof-top cafe (only accessible once you’re in), which serves up fresh air, light snacks and wonderful views over Piazza della Signoria and beyond.