Laguna de Ibans
The small traditional coastal communities around Laguna de Ibans are likely to be your first overnight stop if you enter the Moskitia via the overland route. Pick your base from a cluster of small settlements – Cocobila, Raista and Belén. All have good budget accommodations and are a short walk apart.
Reserva de la Biósfera del Río Plátano
The Río Plátano Biosphere Reserve is a magnificent nature reserve, declared a World Heritage Site in 1980. A vast, unspoiled and untamed wilderness, it's home to extraordinary animal life, including a number of endangered species. The best time to visit is from November to July, though bird-watchers should come in February and March, when many migratory birds are here.
Beside the lagoon of the same name, Brus Laguna is an accessible entry point to the Moskitia, as it has an airport. You can head to Raista or even straight to Las Marías from here. There are a couple of internet places here, but no bank. Note that there's now a large US DEA (Drug Enforcement Agency) and Honduran military presence in the area due to increased narco activities.