Getting there & away
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Train
Train travel is tricky out of Sancti Spíritus. Luckily, the train station (2-4790; Av Jesús Menéndez final; ticket window 7am-2pm Mon-Sat), southwest of the Puente Yayabo, is an easy 10-minute walk from town so you can check schedules and status. The only departures from Sancti Spíritus proper are to Habana (CUC$14, eight hours, 376km, 9pm alternate days), stopping in Santa Clara (CUC$4, two hours, 83km), and to Cienfuegos (CUC$5.50, five hours, 164km, 4am Monday).
Points east are served out of Guayos, 15km north of Sancti Spíritus, including Holguín (CUC$14, 8½ hours, 9.30am), Bayamo (CUC$13, 8¼ hours, 394km) and Santiago de Cuba (CUC$21, 10¼ hours, 8.45am). If you're on the Habana-Santiago de Cuba cross-country express and going to Sancti Spíritus or Trinidad, you have to get off at Guayos.
The ticket office at the Sancti Spíritus train station can sell you tickets for the trains from Guayos, but you must find your own way there (CUC$8 to CUC$10 in a taxi but bargain hard).
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