A relatively recent addition to La Paz's collection of religious structures, the 1835 cathedral is an impressive structure. The cathedral's sheer immensity, with its high dome, hulking columns, thick stone walls and high ceilings, is overpowering, but the altar is relatively simple. Inside, the main attraction is the profusion of stained-glass work.

Beside the cathedral is the Presidential Palace, and in the center of Plaza Murillo, opposite, stands a statue of President Gualberto Villarroel. In 1946, he was dragged from the palace by vigilantes and hanged from a lamppost in the square. Interestingly enough, Don Pedro Domingo Murillo, for whom the plaza was named, met a similar fate here in 1810.